What Is TPO? A Medical Affairs Framework for Closing Care Gaps

Medical Affairs teams have spent years talking about impact. The harder question is how to build the systems, goals, and accountability structures that make impact repeatable, not just aspirational.

Troels Sørensen (Global Head of Clinical Practice, Boehringer Ingelheim) joined Scott Thompson, Co-CEO of Acceleration Point, for a webinar on care gap analysis and Target Population Output methodology. Drawing on over 25 years of experience applying this framework across Roche, AstraZeneca, and Novartis, Troels walked Medical Affairs leaders through how to define meaningful care gaps, translate them into accountability-based goals, and build the organizational structures that turn methodology into daily practice. Over 62 leaders submitted questions during the live session.

This article breaks down the core concepts and practical guidance that came out of that conversation.